Natalia Osipova was born in Moscow. She started going into ballet since she was 5. At the age of 8 she entered the Mikhail Lavrovsky Ballet School. In 1995-2004, she studied at the Moscow Choreographic Academy with Marina Kotova and Marina Leonova. At the age of 18 she joined the corps de ballet of the Bolshoi Theatre. In 2006, she became a soloist, a leading soloist in 2008, a principal dancer in 2010. In December 2011, she joined the Mikhailovsky Ballet Company.